Research Catalog

Title

QuaSAR, quantitative structure activity relationships of analgesics, narcotic antagonists, and hallucinogens / editors, Gene Barnett, Milan Trsic, Robert E. Willette.

Publication

Rockville, Md. : Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration ; Washington : for sale by Supt. of Docs., U.S. Govt. Print. Off., [1978]

Items in the Library & Off-site

Details

Additional Authors

• Barnett, Gene
• Trsic, Milan
• Willette, Robert E.
• National Institute on Drug Abuse

Description

ix, 487 p. : ill.; 24 cm.

Series Statement

• DHEW publication ; no. (ADM) 78-729
• NIDA research monograph ; 22

Uniform Title

• NIDA research monograph 22.
• DHEW publication no. (ADM) 78-729.

Subjects

• Analgesics
• Drugs > Structure-activity relationships
• Hallucinogenic drugs > Analysis
• Analgesics > Analysis
• Narcotic antagonists > Analysis
• Drug Antagonism
• Hallucinogens
• Narcotic Antagonists
• Structure-Activity Relationship
• Congress

Genre/Form

Congress

Note

• "Proceedings of a technical review meeting held by the National Institute on Drug Abuse during April 20-22, 1978, entitled Quantitative Structure Activity Relationship (QuaSAR) of Narcotic Analgesics, Narcotic Antagonists and Hallucinogens"--P. 1.

Bibliography (note)

• Includes bibliographies.

Processing Action (note)

• committed to retain

Contents

• Section I. Pharmacochemical Methods -- Absolute configuration and psychotomimetic activity / George M. Anderson III, Gisela Braun, Ulrich Braun, David E. Nichols, and Alexander Shulgin -- Congeners of DOM: effect of distribution on the evaluation of pharmacologic data / C.F. Barfknecht, J.F. Caputo, M.B. Tobin, D.C. Dyer, R.T. Standridge, H.G. Howell, W.R. Goodwin, R.A. Partyka, J.A. Gylys, R.L. Cavanagh -- Mescaline analogs: substitutions at the 4-position / Ulrich Braun, Gisela Braun, Peyton Jacob III, David E. Nichols, and Alexander T. Shulgin -- Defining the histamine H₂-receptor in brain: the interaction with LSD / Jack Peter Green, Harel Weinstein, and Saul Maayani -- The nature of opioid and LSD receptors: structural activity relationship implications / William R. Martin -- The use of rigid analogues to probe hallucinogen receptors / David E. Nichols, Herschel J.R. Weintraub, William R. Pfister, and George K.W. Yim -- Section II. Hansch Analysis and Other Empirical Methods -- QSAR: a critical appraisal / Sydney Archer -- QSAR of agents involved in serotonin and LSD binding sites / Y.L. Chan, E.J. Lien, and J.C. Shih -- Structure activity studies by means of the SIMCA pattern recognition methodology / J. Dunn and Svante Wold -- Quantitative relationship between antinociceptive and opiate receptor affinity: the importance of lipophilicity / Arthur E. Hacobson -- Quantitative stereo-structure-activity relationships I. opiate receptor binding / Howard Johnson -- Progress with several models for the study of the SAR of hallucinogenic agents / Lemont B. Kier and Richard A. Glennon -- QSAR of narcotic analgetic agents / E.J. Lien, G.L. Tong, D.B. Srulevitch, and C. Dias -- Section III. Molecular Mechanics -- Quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines / George M. Anderson III, Neal Castagnoli, Jr., and Peter A. Kollman -- Assessment of quantum mechanical techniques for use in structure activity relationship development, and application to analgesics and other drugs / B. Vernon Cheney, D.J. Duchamp, Ralph E. Christoffersen.
• Section III. Molecular Mechanics (cont.) -- Recent physiochemical and quantum chemical studies on drugs of abuse and relevant biomolecules / Joyce J. Kaufman -- Structure-activity studies of narcotic agonists and antagonists from quantum chemical calculations / Gilda H. Loew, Donald S. Berkowitz, and Stanley K. Burt -- An extended isolated molecule method and its applications to the design of new drugs: general aspects / Alfredo M. Simas, Roy E. Bruns, and Richard E. Brown -- Recognition and activation mechanisms on the LSD/Serotonin receptor: the molecular basis of structure activity relationships / Harel Weinstein, Jack Peter Green, Roman Osman, and W. Daniel Edwards -- Conformational energies and geometries of narcotics, using a potential function method / Mark Froimowitz -- Conformational study of lysergic acid derivatives in relation to their hallucinogenic and antiserotonin activities / Mahadevappa Kumbar -- Section IV. Spectroscopic Methods -- Carbon-13 nuclear magnetic resonance study of the alpha- and beta- isomers of methadol and acetylmethadol hydrochlorides / F. Ivy Carroll, Charles G. Moreland, George A. Brine, and Karl G. Boldt -- Photoelectron spectroscopic studies of hallucinogens: the use of ionization potentials in QSAR / L.N. Domelsmith and K.N. Houk -- An assessment of parameters in QuaSAR studies of narcotic analgesics and antagonists / Robert Katz, Steven Osborne, Florin Ionescu, Peter Andrulis, Jr., Robert Bates, William Beavers, Paul C.C. Chou, Gilda Loew, and Donald Berkowitz -- Conformational studies on phenethylamine hallucinogens the role of alpha alkyl substitution / Alexandros Makriyannis and James Knittel -- Appendix A. QuaSAR program -- Appendix B. List of participants.

LCCN

^^^78600104^//r886

OCLC

• 5241050
• SCSB-14230976

Owning Institutions

Harvard Library